Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Health-Related Quality of Life in Sepsis.

ABSTRACT: Patients who experience sepsis often have long-term effects that may impact health-related quality of life. This study aimed to investigate whether the combination of ascorbic acid, corticosteroids, and thiamine compared with placebo improves health-related quality of life in patients with septic shock.

Design

Secondary analysis of the Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis randomized controlled trial (NCT03389555).

Setting

Thirteen tertiary-care hospitals in the United States.

Patients

Patients who were enrolled in Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis, survived to 90 days post enrollment and were able to be contacted by telephone.

Interventions

Patients were randomly assigned to parenteral ascorbic acid (1,500 mg), hydrocortiso

SUBMITTER: Grossestreuer AV 

PROVIDER: S-EPMC7685963 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature