Characterization of the Progression From Ambulatory to Hospitalized Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Some patients develop elevated filling pressures exclusively during exercise and never require hospitalization, whereas others periodically develop congestion that requires inpatient treatment. The features differentiating these cohorts are unclear.

Methods

We performed a secondary analysis of 7 National Institutes of Health-sponsored multicenter trials of HFpEF (EF ≥ 50%, N = 727). Patients were stratified by history of hospitalization because of HF, comparing patients never hospitalized (HFpEF_NH) to those with a prior hospitalization (HFpEF_PH). Currently hospitalized (HFpEF_CH) patients were included to fill the spectrum. Clinical characterist

SUBMITTER: Reddy YNV 

PROVIDER: S-EPMC7704788 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature