Ontology highlight
ABSTRACT:
SUBMITTER: Kamps D
PROVIDER: S-EPMC7710677 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kamps Dominic D Koch Johannes J Juma Victor O VO Campillo-Funollet Eduard E Graessl Melanie M Banerjee Soumya S Mazel Tomáš T Chen Xi X Wu Yao-Wen YW Portet Stephanie S Madzvamuse Anotida A Nalbant Perihan P Dehmelt Leif L
Cell reports 20201201 9
Local cell contraction pulses play important roles in tissue and cell morphogenesis. Here, we improve a chemo-optogenetic approach and apply it to investigate the signal network that generates these pulses. We use these measurements to derive and parameterize a system of ordinary differential equations describing temporal signal network dynamics. Bifurcation analysis and numerical simulations predict a strong dependence of oscillatory system dynamics on the concentration of GEF-H1, an Lbc-type R ...[more]