Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals: A Genome-Wide Association Study and Meta-analysis.

ABSTRACT:

Importance

The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully understood.

Objective

To explore the genetic basis of BD in the Han Chinese population.

Design, setting, and participants

A genome-wide association study (GWAS), followed by independent replication, was conducted to identify BD risk loci in Han Chinese individuals. Individuals with BD were diagnosed based on DSM-IV criteria and had no history of schizophrenia, mental retardation, or substance dependence; individuals without any personal or family history of mental illnesses, including BD, were included as control participants. In total, discovery samples from 1822 patients and 4650 control participants passed quality control for the GWAS analysis. Replication analyses of samp

SUBMITTER: Li HJ 

PROVIDER: S-EPMC7711567 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature