Inhibition of LTβR signalling activates WNT-induced regeneration in lung.

ABSTRACT: Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures^1,2, which are associated with severe chronic inflammatory diseases that span several organ systems^3-6. How LTβR signalling drives chronic tissue damage particularly in the lung, the mechanism(s) that regulate this process, and whether LTβR blockade might be of therapeutic value have remained unclear. Here we demonstrate increased expression of LTβR ligands in adaptive and innate immune cells, enhanced non-canonical NF-κB signalling, and enriched LTβR target gene expression in lung epithelial cells from patients with smoking-associated chronic obstructive pulmonary disease (COPD) and from mice chronically exposed to cigarette smoke. Therapeutic inhi

SUBMITTER: Conlon TM 

PROVIDER: S-EPMC7718297 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature