Ontology highlight
ABSTRACT:
SUBMITTER: Baardman J
PROVIDER: S-EPMC7722882 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Nature communications 20201208 1
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosclerotic plaques. We demonstrate that myeloid Acly deficiency induces a stable plaque phenotype characteri ...[more]