Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk.

ABSTRACT:

Background

Hereditary factors contributed to breast cancer susceptibility. Low BRCA mutation prevalence was demonstrated in previous BRCA mutation screening in Chinese breast cancer patients. Multiple-gene sequencing may assist in discovering detrimental germline mutation in.

Brca

negative breast cancers.

Methods

A total of 384 Chinese subjects with any two of high-risk factors were recruited and screened by next-generation sequencing (NGS) for 30 cancer susceptible genes. Variants with a truncating, initiation codon or splice donor/acceptor effect, or with pathogenicity demonstrated in published literature were classified into pathogenic/likely-pathogenic mutations.

Results

In total, we acquired 39 (10.2%) patients with pathogenic/likely-pathogen

SUBMITTER: Lang GT 

PROVIDER: S-EPMC7723566 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature