TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.

ABSTRACT: Antigen-presenting conventional dendritic cells (cDCs) are broadly divided into type 1 and type 2 subsets that further adapt their phenotype and function to perform specialized tasks in the immune system. The precise signals controlling tissue-specific adaptation and differentiation of cDCs are currently poorly understood. We found that mice deficient in the Ste20 kinase Thousand and One Kinase 3 (TAOK3) lacked terminally differentiated ESAM⁺ CD4⁺ cDC2s in the spleen and failed to prime CD4⁺ T cells in response to allogeneic red-blood-cell transfusion. These NOTCH2- and ADAM10-dependent cDC2s were absent selectively in the spleen, but not in the intestine of Taok3^-/- and CD11c-cre Taok3^fl/fl mice. The loss of splenic ESAM

SUBMITTER: Vanderkerken M 

PROVIDER: S-EPMC7733863 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature