A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.

ABSTRACT:

Background

Prognostic markers for meningioma are needed to risk-stratify patients and guide postoperative surveillance and adjuvant therapy.

Objective

To identify a prognostic gene signature for meningioma recurrence and mortality after resection using targeted gene-expression analysis.

Methods

Targeted gene-expression analysis was used to interrogate a discovery cohort of 96 meningiomas and an independent validation cohort of 56 meningiomas with comprehensive clinical follow-up data from separate institutions. Bioinformatic analysis was used to identify prognostic genes and generate a gene-signature risk score between 0 and 1 for local recurrence.

Results

We identified a 36-gene signature of meningioma recurrence after resection that achieved an area under the

SUBMITTER: Chen WC 

PROVIDER: S-EPMC7735867 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature