NIR-Absorbing Ru^II Complexes Containing α-Oligothiophenes for Applications in Photodynamic Therapy.

ABSTRACT: The design of near-infrared (NIR)-active photosensitizers (PSs) for light-based cancer treatments such as photodynamic therapy (PDT) has been a challenge. While several NIR-Ru^II scaffolds have been reported, this approach has not been proven in cells. This is the first report of NIR-Ru^II PSs that are phototoxic to cancer cells, including highly pigmented B16F10 melanoma cells. The PS family incorporated a bis(1,8-naphthyridine)-based ligand (tpbn), a bidentate thiophene-based ligand (nT; n=0-4), and a monodentate 4-picoline ligand (4-pic). All compounds absorbed light >800 nm with maxima near 730 nm. Transient absorption (TA) measurements indicated that n=4 thiophene rings (4T) positioned the PDT-active triplet intraligand charge transfer (³ ILCT) excited s

SUBMITTER: Lifshits LM 

PROVIDER: S-EPMC7736147 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature