Mind-Wandering in Adolescents Predicts Worse Affect and Is Linked to Aberrant Default Mode Network-Salience Network Connectivity.

ABSTRACT:

Objective

Understanding the fluctuating emotional and cognitive states of adolescents with depressive symptoms requires fine-grained and naturalistic measurements. This study used ecological momentary assessment (EMA) to investigate the affective correlates and consequences of mind-wandering in adolescents with anhedonia (AH) and typically developing (TD) controls. In addition, we examined the association between mind-wandering and resting state functional connectivity between the medial prefrontal cortex (mPFC), a core hub of the default mode network (DMN) linked to internally oriented mentation, and networks linked to attentional control (dorsal attention network [DAN]) and affect/salience detection (salience network [SN]).

Method

A total of 65 adolescents, aged 12 to 18 years (TD = 36; AH = 29), completed a resting state functional magnetic resonance imaging scan and subsequently used a smartphone application for ecological momentary assessment (EMA) data collection (2-3 times/d for 5 days). Each survey (N = 678) prompted adolescents to report on their current positive and negative affect (PA and NA), cognition, and activity.

Results

The frequency of mind-wandering was higher for AH (70.0% of EMA samples) relative to TD (59.2%) participants, and the participants with AH were more likely to mind-wander to unpleasant content. Mind-wandering was associated with higher concurrent NA, even when controlling for plausible confounds (eg, current activity, social companion, rumination). Time-lagged analyses revealed a bidirectional association between mind-wandering and PA. Greater levels of mind-wandering within the AH group were associated with stronger mPFC-SN/DAN connectivity.

Conclusion

Rates of mind-wandering were high, especially among adolescents with anhedonia, and predicted worse affect. The relation between mind-wandering and enhanced mPFC-SN coupling may reflect heightened bottom-up influence of affective and sensory salience on DMN-mediated internally oriented thought.

SUBMITTER: Webb CA 

PROVIDER: S-EPMC7736484 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature