Lactate Dehydrogenase Inhibition With Oxamate Exerts Bone Anabolic Effect.

ABSTRACT: Cellular bioenergetics is a promising new therapeutic target in aging, cancer, and diabetes because these pathologies are characterized by a shift from oxidative to glycolytic metabolism. We have previously reported such glycolytic shift in aged bone as a major contributor to bone loss in mice. We and others also showed the importance of oxidative phosphorylation (OxPhos) for osteoblast differentiation. It is therefore reasonable to propose that stimulation of OxPhos will have bone anabolic effect. One strategy widely used in cancer research to stimulate OxPhos is inhibition of glycolysis. In this work, we aimed to evaluate the safety and efficacy of pharmacological inhibition of glycolysis to stimulate OxPhos and promote osteoblast bone-forming function and bone anabolism. We tested a ran

SUBMITTER: Hollenberg AM 

PROVIDER: S-EPMC7736558 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature