Unknown

Dataset Information

0

YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.

ABSTRACT: Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are severely understudied. In addition, little is known regarding the role of m6A reader YTHDF3 in human diseases. Here, we show that YTHDF3 overexpression clinically correlates with brain metastases in breast cancer patients. YTHDF3 promotes cancer cell interactions with brain endothelial cells and astrocytes, blood-brain barrier extravasation, angiogenesis, and outgrow. Mechanistically, YTHDF3 enhances the translation of m6A-enriched transcripts for ST6GALNAC5, GJA1, and EGFR, all associated with brain metastasis. Furthermore, overexpression of YTHDF3 in brain metastases is attributed to increased gene copy number and the autoregulation of YTHDF3 cap-independent translation by binding to m6A residues within its own 5' UTR. Our work uncovers an essential role of YTHDF3 in controlling the interaction between cancer cells and brain microenvironment, thereby inducing brain metastatic competence.

SUBMITTER: Chang G 

PROVIDER: S-EPMC7738369 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

YTHDF3 Induces the Translation of m<sup>6</sup>A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.

Chang Guoqiang G   Shi Lei L   Ye Youqiong Y   Shi Hailing H   Zeng Lixian L   Tiwary Shweta S   Huse Jason T JT   Huo Lei L   Ma Li L   Ma Yongjie Y   Zhang Sicong S   Zhu Jianwei J   Xie Victoria V   Li Peng P   Han Leng L   He Chuan C   Huang Suyun S  

Cancer cell 20201029 6

Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are severely understudied. In addition, little is known regarding the role of m<sup>6</sup>A reader YTHDF3 in human diseases. Here, we show that YTHDF3 overexpression clinically correlates with brain metastases in breast cancer patients. YTHDF3 promotes cancer cell interactions with brain endothelial cells and astrocytes, blood-brain barrier extravasation, angiogenesis, and outgrow. Mechanistically, YTHDF3 enhanc  ...[more]

Similar Datasets

Transcriptomics YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis
2020-09-30 | GSE130173 | GEO
Transcriptomics YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis [m6A-seq]
2020-09-30 | GSE130172 | GEO
Transcriptomics YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis [RIP-Seq]
2020-09-30 | GSE130171 | GEO
Genomics YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis
| PRJNA534211 | ENA
Genomics YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis [RIP-Seq]
| PRJNA534213 | ENA
Genomics YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis [m6A-seq]
| PRJNA534214 | ENA
Unknown Cytoplasmic m<sup>6</sup>A reader YTHDF3 promotes mRNA translation.
| S-EPMC5339832 | biostudies-literature
Unknown YTHDF3 facilitates translation and decay of N<sup>6</sup>-methyladenosine-modified RNA.
| S-EPMC5339834 | biostudies-literature
Unknown Autophagy induction promoted by m<sup>6</sup>A reader YTHDF3 through translation upregulation of FOXO3 mRNA.
| S-EPMC9532426 | biostudies-literature
Unknown Quality of Radiomics Research on Brain Metastasis: A Roadmap to Promote Clinical Translation.
| S-EPMC8743155 | biostudies-literature