Dataset Information

Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study.

ABSTRACT:

Background

We established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on the incidence of major diseases, such as cancer and cardiovascular diseases.

Methods

We asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria were aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), such as carotid echography and calcaneal ultrasound bone mineral density. All participants agreed to measure genome information and to distribute their information widely.

Results

As a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants in the Type 1 survey were more likely to have psychological distress than those in the Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents, regardless of sex.

Conclusion

This cohort comprised a large sample size and it contains information on the natural disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of the disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.

SUBMITTER: Hozawa A

PROVIDER: S-EPMC7738642 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study.

Hozawa Atsushi A Tanno Kozo K Nakaya Naoki N Nakamura Tomohiro T Tsuchiya Naho N Hirata Takumi T Narita Akira A Kogure Mana M Nochioka Kotaro K Sasaki Ryohei R Takanashi Nobuyuki N Otsuka Kotaro K Sakata Kiyomi K Kuriyama Shinichi S Kikuya Masahiro M Tanabe Osamu O Sugawara Junichi J Suzuki Kichiya K Suzuki Yoichi Y Kodama Eiichi N EN Fuse Nobuo N Kiyomoto Hideyasu H Tomita Hiroaki H Uruno Akira A Hamanaka Yohei Y Metoki Hirohito H Ishikuro Mami M Obara Taku T Kobayashi Tomoko T Kitatani Kazuyuki K Takai-Igarashi Takako T Ogishima Soichi S Satoh Mamoru M Ohmomo Hideki H Tsuboi Akito A Egawa Shinichi S Ishii Tadashi T Ito Kiyoshi K Ito Sadayoshi S Taki Yasuyuki Y Minegishi Naoko N Ishii Naoto N Nagasaki Masao M Igarashi Kazuhiko K Koshiba Seizo S Shimizu Ritsuko R Tamiya Gen G Nakayama Keiko K Motohashi Hozumi H Yasuda Jun J Shimizu Atsushi A Hachiya Tsuyoshi T Shiwa Yuh Y Tominaga Teiji T Tanaka Hiroshi H Oyama Kotaro K Tanaka Ryoichi R Kawame Hiroshi H Fukushima Akimune A Ishigaki Yasushi Y Tokutomi Tomoharu T Osumi Noriko N Kobayashi Tadao T Nagami Fuji F Hashizume Hiroaki H Arai Tomohiko T Kawaguchi Yoshio Y Higuchi Shinichi S Sakaida Masaki M Endo Ryujin R Nishizuka Satoshi S Tsuji Ichiro I Hitomi Jiro J Nakamura Motoyuki M Ogasawara Kuniaki K Yaegashi Nobuo N Kinoshita Kengo K Kure Shigeo S Sakai Akio A Kobayashi Seiichiro S Sobue Kenji K Sasaki Makoto M Yamamoto Masayuki M

Journal of epidemiology 20200111 1

<h4>Background</h4>We established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on the incidence of major diseases, such as cancer and cardiovascular diseases.<h4>Methods</h4>We asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria were aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained informati ...[more]

PMID: 31932529

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Project description:BackgroundUpper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults.MethodsWe conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors.ResultsGrip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively.ConclusionsGrip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.

Project description:The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.

Dataset Information

Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study.

Background

Methods

Results

Conclusion

Publications

Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study.

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