A prospective safety and feasibility study of metered cryospray for patients with chronic bronchitis in COPD.

ABSTRACT:

Background

No currently approved intervention counteracts airway metaplasia and mucus hypersecretion of chronic bronchitis in COPD. However, metered cryospray (MCS) delivering liquid nitrogen to the tracheobronchial airways ablates abnormal epithelium and facilitates healthy mucosal regeneration. The objective of this study was to evaluate the feasibility, efficacy and safety of MCS in chronic bronchitis.

Methods

Patients with a forced expiratory volume in 1 s of 30-80% predicted who were taking optimal medication were recruited. Primary outcomes were feasibility (completion of treatments), efficacy (3-month change in St George's Respiratory Questionnaire (SGRQ)) and safety (incidence of adverse events). Secondary outcomes were lung function, exercise capacity and additional

SUBMITTER: Garner JL 

PROVIDER: S-EPMC7744607 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature