Bronchial rheoplasty for chronic bronchitis: 2-year results from a US feasibility study with RheOx.

ABSTRACT:

Introduction

Chronic bronchitis (CB), a phenotype of chronic obstructive pulmonary disease (COPD) characterised by persistent cough and mucus hypersecretion, is associated with poor outcomes despite guideline-based treatment. Bronchial rheoplasty (BR) with the RheOx system delivers non-thermal pulsed electric fields to the lower airway epithelium and submucosa to reduce mucus producing cells. Early phase clinical trials including 1-year follow-up have demonstrated reduction in airway goblet cell hyperplasia and improvement in CB symptoms.

Methods

The current multicentre observational BR study enrolled 21 patients with CB at six centres in the USA, with bilateral treatment and 2-year follow-up. Entry criteria included elevated cough and sputum scores from COPD Assessment Test

SUBMITTER: Sciurba FC 

PROVIDER: S-EPMC10753755 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature