Long-term spatial tracking of cells affected by environmental insults.

ABSTRACT:

Background

Harsh environments surrounding fetuses and children can induce cellular damage in the developing brain, increasing the risk of intellectual disability and other neurodevelopmental disorders such as schizophrenia. However, the mechanisms by which early damage leads to disease manifestation in later life remain largely unknown. Previously, we demonstrated that the activation of heat shock (HS) signaling can be utilized as a unique reporter to label the cells that undergo specific molecular/cellular changes upon exposure to environmental insults throughout the body. Since the activation of HS signaling is an acute and transient event, this approach was not intended for long-term tracing of affected cells after the activation has diminished. In the present study, we generate

SUBMITTER: Mohammad S 

PROVIDER: S-EPMC7745478 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature