Proteostasis is adaptive: Balancing chaperone holdases against foldases.

ABSTRACT: Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to different conditions? Here, we explore a biophysical cost-benefit principle, namely that the cell should keep its proteome as folded as possible at the minimum possible energy cost. This can be achieved by differential expression of chaperones-balancing foldases (which accelerate folding) against holdases (which act as parking spots). The model captures changes in the foldase-holdase ratio observed both within organisms during aging and across organisms of varying metabolic rates. This work describes a simple biophysical mechanism by which cellular proteostasis adapts to meet the needs of a changing growth environment.

SUBMITTER: de Graff AM 

PROVIDER: S-EPMC7769611 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature