Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. Most previous studies that identified genetic risks for ARDS focused on candidates with biological relevance. We aimed to identify novel genetic variants associated with ARDS susceptibility and to provide complementary functional evidence of their effect in gene regulation.

Methods

We did a case-control genome-wide association study (GWAS) of 1935 European individuals, using patients with sepsis-associated ARDS as cases and patients with sepsis without ARDS as controls. The discovery stage included 672 patients admitted into a network of Spanish intensive care units between January, 2002, and January, 2017. The replication stage comprised 1345 individuals from two in

SUBMITTER: Guillen-Guio B 

PROVIDER: S-EPMC7772505 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature