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Development and sex modulate visuospatial oscillatory dynamics in typically-developing children and adolescents.

ABSTRACT: Visuospatial processing is a cognitive function that is critical to navigating one's surroundings and begins to develop during infancy. Extensive research has examined visuospatial processing in adults, but far less work has investigated how visuospatial processing and the underlying neurophysiology changes from childhood to early adolescence, which is a critical period of human development that is marked by the onset of puberty. In the current study, we examined behavioral performance and the oscillatory dynamics serving visuospatial processing using magnetoencephalography (MEG) in a cohort of 70 children and young adolescents aged 8-15 years. All participants performed a visuospatial processing task during MEG, and the resulting oscillatory responses were imaged using a beamformer and probed for developmental and sex-related differences. Our findings indicated that reaction time on the task was negatively correlated with age, and that the amplitude of theta oscillations in the medial occipital cortices increased with age. Significant sex-by-age interactions were also detected, with female participants exhibiting increased theta oscillatory activity in the right prefrontal cortex with increasing age, while male participants exhibited theta increases in the left parietal lobe/left precuneus and left supplementary motor area with increasing age. These data indicate that different nodes of the visuospatial processing network develop earlier in males compared to females (and vice versa) in this age range, which may have major implications for the developmental trajectory of behavioral performance and executive function more generally during the transition through puberty.

SUBMITTER: Killanin AD

PROVIDER: S-EPMC7779241 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Development and sex modulate visuospatial oscillatory dynamics in typically-developing children and adolescents.

Killanin Abraham D AD Wiesman Alex I AI Heinrichs-Graham Elizabeth E Groff Boman R BR Frenzel Michaela R MR Eastman Jacob A JA Wang Yu-Ping YP Calhoun Vince D VD Stephen Julia M JM Wilson Tony W TW

NeuroImage 20200722

Visuospatial processing is a cognitive function that is critical to navigating one's surroundings and begins to develop during infancy. Extensive research has examined visuospatial processing in adults, but far less work has investigated how visuospatial processing and the underlying neurophysiology changes from childhood to early adolescence, which is a critical period of human development that is marked by the onset of puberty. In the current study, we examined behavioral performance and the o ...[more]

PMID: 32711061

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Project description:The ability to dynamically allocate neural resources within the visual space is supported by a number of spectrally-specific oscillatory responses, and such visuospatial processing has been found to decline moderately with age and differ by sex. However, the direct effects of age and sex on these oscillatory dynamics remains poorly understood. Using magnetoencephalography (MEG), structural magnetic resonance imaging, and advanced source reconstruction and statistical methods, we investigated the impact of aging and sex on behavioral performance and the underlying neural dynamics during visuospatial processing. In a large sample spanning a broad age range, we find that a number of prototypical attention and perception network components, both spectrally- and spatially-defined, exhibit complex and uniquely informative relationships with age and sex. Specifically, neural responses in the theta range (4-10 Hz) were found to covary with chronological age in prefrontal and motor cortices, signifying a possible relationship between age and cognitive control. Further, we found that beta (18-24 Hz) activity covaried with age across a large swath of the somato-motor strip, supporting previous findings of motor planning and execution deficits with increasing age. Finally, gamma-frequency (48-70 Hz) oscillations were found to exhibit robust covariance with age in superior parietal and temporo-parietal areas, indicating that the mapping of saliency in visual space is modulated by the normal aging process. Interestingly, behavioral performance and some of these oscillatory neural responses also exhibited interactions between age and sex, indicating sex differences in the evolution of the neural coding of visual perception as age increases. In particular, men were found to have stronger correlations between age and neural oscillatory responses during task performance than women in lateral occipital and superior temporal regions in the alpha band and in dorsolateral prefrontal cortex in the gamma band, while women exhibited more robust covariance between age and neural responses than men in inferior temporal and medial prefrontal cortex in the theta range.

Dataset Information

Development and sex modulate visuospatial oscillatory dynamics in typically-developing children and adolescents.

Publications

Development and sex modulate visuospatial oscillatory dynamics in typically-developing children and adolescents.

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