Cancer-derived sialylated IgG promotes tumor immune escape by binding to Siglecs on effector T cells.
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ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC7784903 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Cancer-derived sialylated IgG promotes tumor immune escape by binding to Siglecs on effector T cells.
Wang Zihan Z Geng Zihan Z Shao Wenwei W Liu Enyang E Zhang Jingxuan J Tang Jingshu J Wang Pingzhang P Sun Xiuyuan X Xiao Lin L Xu Weiyan W Zhang Youhui Y Cui Heng H Zhang Liang L Yang Xi X Chang Xiaohong X Qiu Xiaoyan X
Cellular & molecular immunology 20191121 11
To date, IgG in the tumor microenvironment (TME) has been considered a product of B cells and serves as an antitumor antibody. However, in this study, using a monoclonal antibody against cancer-derived IgG (Cancer-IgG), we found that cancer cells could secrete IgG into the TME. Furthermore, Cancer-IgG, which carries an abnormal sialic acid modification in the CH1 domain, directly inhibited effector T-cell proliferation and significantly promoted tumor growth by reducing CD4<sup>+</sup> and CD8<s ...[more]
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