Alternatively Activated Macrophages Drive Browning of White Adipose Tissue in Burns.

ABSTRACT:

Objective

The aim of this study was to uncover the mediators and mechanistic events that facilitate the browning of white adipose tissue (WAT) in response to burns.

Background

In hypermetabolic patients (eg, burns, cancer), the browning of WAT has presented substantial clinical challenges related to cachexia, atherosclerosis, and poor clinical outcomes. Browning of the adipose tissue has recently been found to induce and sustain hypermetabolism. Although browning appears central in trauma-, burn-, or cancer-induced hypermetabolic catabolism, the mediators are essentially unknown.

Methods

WAT and blood samples were collected from patients admitted to the Ross Tilley Burn Centre at Sunnybrook Hospital. Wild type, CCR2 KO, and interleukin (IL)-6 KO male mice were purchas

SUBMITTER: Abdullahi A 

PROVIDER: S-EPMC7805006 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature