Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity.

ABSTRACT: Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (γδ), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent ye

SUBMITTER: de Araujo ND 

PROVIDER: S-EPMC7808823 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature