Ontology highlight
ABSTRACT:
SUBMITTER: Lippert TP
PROVIDER: S-EPMC7820467 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210121 1
To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms to prevent telomere shortening. ~85% of cancers circumvent telomeric attrition by re-expressing telomerase, while the remaining ~15% of cancers induce alternative lengthening of telomeres (ALT), which relies on break-induced replication (BIR) and telomere recombination. Although ALT tumours were first reported over 20 years ago, the mechanism of ALT induction remains unclear and no study to date has de ...[more]