Systematic analysis of enhancer regulatory circuit perturbation driven by copy number variations in malignant glioma.

ABSTRACT: Background: Enhancers are emerging regulatory regions controlling gene expression in diverse cancer types. However, the functions of enhancer regulatory circuit perturbations driven by copy number variations (CNVs) in malignant glioma are unclear. Therefore, we aimed to investigate the comprehensive enhancer regulatory perturbation and identify potential biomarkers in glioma. Results: We performed a meta-analysis of the enhancer centered regulatory circuit perturbations in 683 gliomas by integrating CNVs, gene expression, and transcription factors (TFs) binding. We found widespread CNVs of enhancers during glioma progression, and CNVs were associated with the perturbations of enhancer activities. In particular, the degree of perturbations for amplified enhancers was much grea

SUBMITTER: Xiao J 

PROVIDER: S-EPMC7847679 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature