Ontology highlight
ABSTRACT:
SUBMITTER: Abou Khouzam R
PROVIDER: S-EPMC7854546 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Abou Khouzam Raefa R Brodaczewska Klaudia K Filipiak Aleksandra A Zeinelabdin Nagwa Ahmed NA Buart Stephanie S Szczylik Cezary C Kieda Claudine C Chouaib Salem S
Frontiers in immunology 20210120
The environmental and metabolic pressures in the tumor microenvironment (TME) play a key role in molding tumor development by impacting the stromal and immune cell fractions, TME composition and activation. Hypoxia triggers a cascade of events that promote tumor growth, enhance resistance to the anti-tumor immune response and instigate tumor angiogenesis. During growth, the developing angiogenesis is pathological and gives rise to a haphazardly shaped and leaky tumor vasculature with abnormal pr ...[more]