The complement cascade at the Utah microelectrode-tissue interface.
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ABSTRACT:
SUBMITTER: Bennett C
PROVIDER: S-EPMC7856077 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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The complement cascade at the Utah microelectrode-tissue interface.
Bennett Cassie C Álvarez-Ciara Anabel A Franklin Melissa M Dietrich W Dalton WD Prasad Abhishek A
Biomaterials 20201207
Devices implanted within the central nervous system (CNS) are subjected to tissue reactivity due to the lack of biocompatibility between implanted material and the cells' microenvironment. Studies have attributed blood-brain barrier disruption, inflammation, and oxidative stress as main contributing factors that lead to electrode recording failure. The complement cascade is a part of the innate immunity that focuses on recognizing and targeting foreign objects; however, its role in the context o ...[more]
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