Early Corticosteroid Cessation vs Long-term Corticosteroid Therapy in Kidney Transplant Recipients: Long-term Outcomes of a Randomized Clinical Trial.

ABSTRACT:

Importance

The complications of corticosteroids make the inclusion of these drugs in immunosuppressive protocols for kidney transplant patients undesirable. However, cessation of corticosteroids is associated with a higher risk of short-term rejection, and the long-term outcomes of patients withdrawn from corticosteroids remain uncertain.

Objective

To compare long-term kidney transplant outcomes of patients randomized to continue or withdraw corticosteroids.

Design, setting, and participants

This prospective multicenter randomized double-blind placebo-controlled trial was conducted between November 1999 and December 2002 with linkage to a mandatory national registry with validated outcome ascertainment until June 8, 2018. The study included 28 kidney transplant center

SUBMITTER: Woodle ES 

PROVIDER: S-EPMC7859872 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature