Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations.

ABSTRACT: Background: RAS gene family mutations are the most prevalent in thyroid nodules with indeterminate cytology and are present in a wide spectrum of histological diagnoses. We evaluated differentially expressed genes and signaling pathways across the histological/clinical spectrum of RAS-mutant nodules to determine key molecular determinants associated with a high risk of malignancy. Methods: Sixty-one thyroid nodules with RAS mutations were identified. Based on the histological diagnosis and biological behavior, the nodules were grouped into five categories indicating their degree of malignancy: non-neoplastic appearance, benign neoplasm, indeterminate malignant potential, low-risk cancer, or high-risk cancer. Gene expression profiles of these

SUBMITTER: Hernandez-Prera JC 

PROVIDER: S-EPMC7864115 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature