A comparison of the inflammatory response following autologous compared with allogenic islet cell transplantation.

ABSTRACT:

Background

The initial response to islet transplantation and the subsequent acute inflammation is responsible for significant attrition of islets following both autologous and allogenic procedures. This multicentre study compares this inflammatory response using cytokine profiles and complement activation.

Methods

Inflammatory cytokine and complement pathway activity were examined in two cohorts of patients undergoing total pancreatectomy followed either by autologous (n=11) or allogenic (n=6) islet transplantation. Two patients who underwent total pancreatectomy alone (n=2) served as controls.

Results

The peak of cytokine production occurred immediately following induction of anaesthesia and during surgery. There was found to be a greater elevation of the following c

SUBMITTER: Chung WY 

PROVIDER: S-EPMC7867892 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature