Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC7869975 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lin Hua H Sharabi Kfir K Lin Li L Ruiz Claudia C Zhu Di D Cameron Michael D MD Novick Scott J SJ Griffin Patrick R PR Puigserver Pere P Kamenecka Theodore M TM
Journal of medicinal chemistry 20210112 2
Despite a myriad of available pharmacotherapies for the treatment of type 2 diabetes (T2D), challenges still exist in achieving glycemic control. Several novel glucose-lowering strategies are currently under clinical investigation, highlighting the need for more robust treatments. Previously, we have shown that suppressing peroxisome proliferator-activated receptor gamma coactivator 1-alpha activity with a small molecule (SR18292, <b>16</b>) can reduce glucose release from hepatocytes and amelio ...[more]