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Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.

ABSTRACT: UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A. After providing a brief historical perspective on UV-DDB, we review our current knowledge of the structure and function of this intriguing repair protein. Finally, this article discusses emerging data suggesting that UV-DDB may have other non-canonical roles in base excision repair and the etiology of cancer.

SUBMITTER: Beecher M

PROVIDER: S-EPMC7873659 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.

Beecher Maria M Kumar Namrata N Jang Sunbok S Rapić-Otrin Vesna V Van Houten Bennett B

DNA repair 20200427

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A. After providing a brief historical perspective on UV-DDB, we review our current knowledg ...[more]

PMID: 32739133

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