The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.

ABSTRACT:

Objectives

To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages.

Methods

A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).

Results

As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.<

SUBMITTER: Picillo M 

PROVIDER: S-EPMC7880965 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature