Ontology highlight
ABSTRACT:
SUBMITTER: Zeng J
PROVIDER: S-EPMC7896067 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zeng Jian J Xue Angli A Jiang Longda L Lloyd-Jones Luke R LR Wu Yang Y Wang Huanwei H Zheng Zhili Z Yengo Loic L Kemper Kathryn E KE Goddard Michael E ME Wray Naomi R NR Visscher Peter M PM Yang Jian J
Nature communications 20210219 1
Understanding how natural selection has shaped genetic architecture of complex traits is of importance in medical and evolutionary genetics. Bayesian methods have been developed using individual-level GWAS data to estimate multiple genetic architecture parameters including selection signature. Here, we present a method (SBayesS) that only requires GWAS summary statistics. We analyse data for 155 complex traits (n = 27k-547k) and project the estimates onto those obtained from evolutionary simulat ...[more]