Ontology highlight
ABSTRACT:
SUBMITTER: Park CH
PROVIDER: S-EPMC7897585 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Stem cell reports 20201217 1
Most of our current knowledge regarding early lineage specification and embryo-derived stem cells comes from studies in rodent models. However, key gaps remain in our understanding of these developmental processes from nonrodent species. Here, we report the detailed characterization of pig extraembryonic endoderm (pXEN) cells, which can be reliably and reproducibly generated from primitive endoderm (PrE) of blastocyst. Highly expandable pXEN cells express canonical PrE markers and transcriptiona ...[more]