Dataset Information

Associations of long-term exposure to ambient nitrogen dioxide with indicators of diabetes and dyslipidemia in China: A nationwide analysis.

ABSTRACT:

Background

The associations between ambient NO₂ and diabetes and dyslipidemia have been controversial, and data is especially lacking in developing countries.

Objective

This study aimed to assess the associations of long-term exposure to NO₂ with diabetes and dyslipidemia in China.

Methods

We conducted a cross-sectional study including 13,013 participants from the China Health and Retirement Longitudinal Study (CHRLS). The annual average concentrations of NO₂ were estimated based on the residential addresses of participants. We applied logistic regression models to evaluate the associations of NO₂ with diabetes and dyslipidemia, and linear regression models to assess the associations with blood biomarkers.

Results

A total of 1933 diabetes cases (14.85%) and 1935 (14.87%) dyslipidemia cases were identified. Significant associations were observed between NO₂ and risk of diabetes and dyslipidemia independent of PM_2.5 and O₃. For an interquartile range (IQR) increase in NO₂ (12.39 μg/m³), we observed a 13% [odds ratio (OR): 1.13; 95% confidence interval (CI): 1.01, 1.26] increased risk of diabetes, 1.48% (95%CI: 0.51%, 2.46%) increase in glucose, 0.74% (95%CI: 0.19%, 1.29%) increase in glycosylated hemoglobin (HbA1c), 17% (OR: 1.17; 95% CI: 1.05, 1.31) increased risk of dyslipidemia, 4.62% (95%CI: 2.49%, 6.79%) increase in triglyceride, and a decrease of 2.96% (95%CI: 2.13%, 3.79%) in high-density lipoprotein. The associations of NO₂ with glucose disorders were stronger among smokers.

Conclusions

Our study indicated long-term exposure to NO₂ might contribute to the development of diabetes and dyslipidemia, and the associations were potentially independent of O₃ and PM_2.5.

SUBMITTER: Zhang Q

PROVIDER: S-EPMC7904633 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of long-term exposure to ambient nitrogen dioxide with indicators of diabetes and dyslipidemia in China: A nationwide analysis.

Zhang Qingli Q Liu Cong C Wang Yafeng Y Gong Jinquan J Wang Gewei G Ge Wenzhen W Chen Renjie R Meng Xia X Zhao Yaohui Y Kan Haidong H

Chemosphere 20201024

<h4>Background</h4>The associations between ambient NO<sub>2</sub> and diabetes and dyslipidemia have been controversial, and data is especially lacking in developing countries.<h4>Objective</h4>This study aimed to assess the associations of long-term exposure to NO<sub>2</sub> with diabetes and dyslipidemia in China.<h4>Methods</h4>We conducted a cross-sectional study including 13,013 participants from the China Health and Retirement Longitudinal Study (CHRLS). The annual average concentrations ...[more]

PMID: 33162153

Similar Datasets

Project description:IntroductionA number of population-based studies have investigated long-term effects of nitrogen dioxide (NO2) on mortality, while great heterogeneities exist between studies. In highly populated countries in Asia, cohort evidence for NO2-mortality association was extensively sparse.ObjectivesThis study aimed to quantify longitudinal association of ambient NO2 exposure with all-cause mortality in Chinese adults.MethodsA national cohort of 30,843 adults were drawn from 25 provincial regions across mainland China, and followed up from 2010 through 2018. Participants' exposures to ambient air pollutants were assigned according to their residential counties at baseline, through deriving monthly estimates from high-quality gridded datasets developed by machine learning methods. Cox proportional hazards models with time-varying exposures were utilized to assess the association of all-cause mortality with long-term exposure to ambient NO2. NO2-attributable deaths in China were estimated by province and county for years 2010 and 2018, with reference to the counterfactual exposure of 6.9 μg/m3 (the lowest county-level average in this cohort).ResultsWe observed a total of 1662 deaths during 224020 person-years of follow-up (median 8.1 year). An approximately linear NO2-mortality relation (p = 0.273 for nonlinearity) was identified across a broad exposure range of 6.9-57.4 μg/m3. Per 10-µg/m3 increase in annual NO2 exposure was associated with an hazard ratio of 1.127 (95% confidence interval: 1.042-1.219, p = 0.003) for all-cause mortality. Risk estimates remained robust after additionally adjusting for the confounding effects of co-pollutants (i.e., PM2.5 or/and O3). In 2018, 1.65 million deaths could be attributed to ambient NO2 exposure (national average 17.3 µg/m3) in China, representing a decrease of 4.3% compared with the estimate of 1.72 million in 2010 (20.5 µg/m3).ConclusionThis cohort study provided national evidence for elevated risk of all-cause mortality associated with long-term exposure to ambient NO2 in Chinese adults.

Dataset Information

Associations of long-term exposure to ambient nitrogen dioxide with indicators of diabetes and dyslipidemia in China: A nationwide analysis.

Background

Objective

Methods

Results

Conclusions

Publications

Associations of long-term exposure to ambient nitrogen dioxide with indicators of diabetes and dyslipidemia in China: A nationwide analysis.

Similar Datasets

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