Ontology highlight
ABSTRACT:
SUBMITTER: Pucciarelli D
PROVIDER: S-EPMC7907257 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Pucciarelli Daniela D Angus Steven P SP Huang Benjamin B Zhang Chi C Nakaoka Hiroki J HJ Krishnamurthi Ganesh G Bandyopadhyay Sourav S Clapp D Wade DW Shannon Kevin K Johnson Gary L GL Nakamura Jean L JL
Molecular cancer therapeutics 20200826 11
Loss of the tumor suppressor <i>NF1</i> leads to activation of RAS effector pathways, which are therapeutically targeted by inhibition of mTOR (mTORi) or MEK (MEKi). However, therapeutic inhibition of RAS effectors leads to the development of drug resistance and ultimately disease progression. To investigate molecular signatures in the context of <i>NF1</i> loss and subsequent acquired drug resistance, we analyzed the exomes, transcriptomes, and kinomes of <i>Nf1</i>-mutant mouse tumor cell line ...[more]