A genome-wide association study of asthma hospitalizations in adults.

ABSTRACT:

Background

Little is known about the genetic determinants of severe asthma exacerbations.

Objectives

We aimed to identify genetic variants associated with asthma hospitalizations.

Methods

We conducted a genome-wide association study of asthma hospitalizations in 34,167 white British adults with asthma, 1,658 of whom had at least 1 asthma-related hospitalization. This analysis was conducted by using logistic regression under an additive genetic model with adjustment for age, sex, body mass index, smoking status, and the first 5 principal components derived from genotypic data. We then analyzed data from 2 cohorts of Latino children and adolescents for replication and conducted quantitative trait locus and functional annotation analyses.

Results

At the chromosome

SUBMITTER: Yan Q 

PROVIDER: S-EPMC7921212 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature