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Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe.

ABSTRACT: Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2-5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.

SUBMITTER: Cadelis MM 

PROVIDER: S-EPMC7922810 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Antimicrobial Metabolites against Methicillin-Resistant <i>Staphylococcus aureus</i> from the Endophytic Fungus <i>Neofusicoccum australe</i>.

Cadelis Melissa M MM   Geese Soeren S   Uy Benedict B BB   Mulholland Daniel R DR   van de Pas Shara J SJ   Grey Alex A   Weir Bevan S BS   Copp Brent R BR   Wiles Siouxsie S  

Molecules (Basel, Switzerland) 20210219 4

Antimicrobial bioassay-guided fractionation of the endophytic fungi <i>Neofusicoccum australe</i> led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (<b>1</b>), along with four known natural products (<b>2</b>-<b>5</b>). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing <b>1</b> to be moderately active towards methicillin-resist  ...[more]

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