Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease.

ABSTRACT:

Introduction

This study characterizes retinal capillary blood flow in subjects with autosomal dominant Alzheimer's disease (ADAD)-causing mutations.

Methods

Carriers of PSEN1 or APP mutations were prospectively recruited and split into early-stage (ES) and late-stage (LS) groups. Controls were normal subjects and non-carriers from the at-risk group. Capillary blood flow was quantified using an optical coherence tomography angiography-based measure of erythrocyte flux through capillary segments. Statistical analyses were adjusted for correlation between two eyes of the same subject.

Results

ES carriers had significantly greater capillary blood flow than controls and LS carriers. ES and LS carriers had significantly greater capillary blood flow heterogenei

SUBMITTER: Singer MB 

PROVIDER: S-EPMC7931411 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature