Dataset Information
Interleukin 6 and depression in patients affected by Covid-19.
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ABSTRACT: Introduction
Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms.Objectives
To assess correlation between IL-6, IL-1β and TNF-α and depressive symptoms. Characterize the depressive symptoms present.Methods
Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yesavage Geriatric Depression Scale was used, associating each item with a neurotransmitter.Results
27 patients included. We did not find correlation between IL-6 levels and the GDS scale score (rho = 0.204; 95% CI -0.192 to 0.543); with IL-1β levels (rho = -0.126; 95% CI -0.490 to 0.276); nor of TNF-α (rho = -0.033; 95% CI -0.416 to 0.360). 3 patients (11.1%) presented score compatible with depressive disorder. It was associated with a deficiency of Noradrenaline and Serotonin.Conclusions
We found no correlation between the levels of IL-6, IL-1β, and TNF-α with the GDS score. Depressive symptomatology is similar to vascular depressions.
SUBMITTER: Serrano Garcia A
PROVIDER: S-EPMC7931695 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Interleukin 6 and depression in patients affected by Covid-19.
Medicina clinica (English ed.) 20210304 7
<h4>Introduction</h4>Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms.<h4>Objectives</h4>To assess correlation between IL-6, IL-1β and TNF-α and depressive symptoms. Characterize the depressive symptoms present.<h4>Methods</h4>Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yes ...[more]
