Dataset Information

Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections.

ABSTRACT:

Background

Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses.

Methods

This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012-2017 were categorized by symptom status.

Results

Antibody response was assessed using hemagglutination inhibition assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in HAI antibodies, and 75.3% had febrile illness. In a logistic regression model, febrile cases had 2.17 times higher odds of a ≥4-fold titer rise compared to asymptomatic cases (95% confidence interval, 1.02-4.64).

Conclusions

Studies relying on serological assays may not generalize to asymptomatic infections.

SUBMITTER: Tricoche AD

PROVIDER: S-EPMC7938177 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections.

Tricoche Alexandria D AD Wagner Abram L AL Balmaseda Angel A Sanchez Nery N Patel Mayuri M Lopez Roger R Schiller Amy A Ojeda Sergio S Frutos Aaron M AM Kuan Guillermina G Gordon Aubree A

The Journal of infectious diseases 20210301 5

<h4>Background</h4>Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses.<h4>Methods</h4>This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012-2017 were categorized by symptom status.<h4>Results</h4>Antibody response was assessed using hemagglutination inhibition assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in ...[more]

PMID: 32668454

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Dataset Information

Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections.

Background

Methods

Results

Conclusions

Publications

Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections.

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