Ontology highlight
ABSTRACT:
SUBMITTER: Laursen NS
PROVIDER: S-EPMC6241527 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20181101 6414
Broadly neutralizing antibodies against highly variable pathogens have stimulated the design of vaccines and therapeutics. We report the use of diverse camelid single-domain antibodies to influenza virus hemagglutinin to generate multidomain antibodies with impressive breadth and potency. Multidomain antibody MD3606 protects mice against influenza A and B infection when administered intravenously or expressed locally from a recombinant adeno-associated virus vector. Crystal and single-particle e ...[more]