SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19.

ABSTRACT:

Objective

To follow serological immune responses of front-line healthcare workers after PCR-confirmed COVID-19 for a mean of 30 weeks, describe the time-course of SARS-CoV-2 spike protein-specific IgG, IgA and IgM levels and to identify associations of the immune response with symptoms, demographic parameters and severity of disease.

Methods

Anti-SARS-CoV-2 S protein-specific IgG, IgA and IgM antibodies were measured at three time points during the 30-week follow-up. COVID-19-specific symptoms were assessed with standardized questionnaires.

Results

95% of the participants mounted an IgG response with only modest decline after week 12. IgG-type antibodies were still detectable in almost 90% of the subjects at 30 weeks. IgA and IgM responses were less robust and antibod

SUBMITTER: Gluck V 

PROVIDER: S-EPMC7944246 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature