Dataset Information

Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity.

ABSTRACT:

Background

Lentinan (LNT) may regulate many important physiological functions of human and animals. This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs.

Methods

Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d (n = 14). RV infection was executed on d 15. After extracting polysaccharides from LNT product, its major monosaccharides were analyzed. Then, LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells.

Results

Dietary LNT supplementation supported normal function of piglets even when infected with RV, as reflected by reduced growth performance loss and diarrhea prevalence, and maintained gut immunity (P < 0.05). The polysaccharide was isolated from LNT product, which molecular weight was 5303 Da, and major monosaccharides included glucose, arabinose and galactose. In RV-infected IPEC-J2 cells, this polysaccharide significantly increased cell viability (P < 0.05), and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides (P < 0.05).

Conclusion

Those results suggest that LNT administration increases the piglets' resistance to RV-induced stress, likely by supporting intestinal immunity.

SUBMITTER: Fan X

PROVIDER: S-EPMC7945689 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity.

Fan Xiangqi X Hu Haiyan H Chen Daiwen D Yu Bing B He Jun J Yu Jie J Luo Junqiu J Eckhardt Erik E Luo Yuheng Y Wang Jianping J Yan Hui H Mao Xiangbing X

Journal of animal science and biotechnology 20210309 1

<h4>Background</h4>Lentinan (LNT) may regulate many important physiological functions of human and animals. This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs.<h4>Methods</h4>Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d (n = 14). RV infection was executed on d 15. After extracting polysaccharides from LNT product, its major monosaccharides were analyze ...[more]

PMID: 33750472

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Dataset Information

Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity.

Background

Methods

Results

Conclusion

Publications

Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity.

Similar Datasets

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