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p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.

ABSTRACT: One new (1) and fifteen known (2-16) p-terphenyls were isolated from a solid culture of the endophytic fungus Aspergillus sp. GZWMJZ-055 by adding the leaves of its host Eucommia ulmoides. Furthermore, nine p-terphenyls (17-25) were synthesized from the main compounds (5-7), among which derivatives 18, 19, 21, 22, and 25 are new p-terphenyls. Compounds 15 and 16 were also, respectively, synthesized from compounds 6 and 7 by oxidative cyclization of air in the presence of silica gel. These p-terphenyls especially those with 4,2',4″-trihydroxy (4-7, 20, 21) or 4, 4″-dihydroxy-1,2,1',2'-furan (15, 16) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.

SUBMITTER: Xu Y

PROVIDER: S-EPMC7947296 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.

Xu Yanchao Y Wang Yong Y Wu Dan D He Wenwen W Wang Liping L Zhu Weiming W

Frontiers in microbiology 20210225

One new (1) and fifteen known (2-16) p-terphenyls were isolated from a solid culture of the endophytic fungus Aspergillus sp. GZWMJZ-055 by adding the leaves of its host Eucommia ulmoides. Furthermore, nine p-terphenyls (17-25) were synthesized from the main compounds (5-7), among which derivatives 18, 19, 21, 22, and 25 are new p-terphenyls. Compounds 15 and 16 we ...[more]

PMID: 33717048

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Dataset Information

p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.

Publications

<i>p</i>-Terphenyls From <i>Aspergillus</i> sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.

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