Survival benefit of perioperative chemotherapy for T1-3N0M0 stage esophageal cancer: a SEER database analysis.

ABSTRACT:

Background

The effect of perioperative chemotherapy on patients with lymph node-negative esophageal cancer (EC) is controversial. This study explored which EC patients, staged under the T1-3N0M0, would benefit from perioperative chemotherapy.

Methods

Data on patients with diagnosed primary EC were retrieved from Surveillance, Epidemiology and End Results (SEER) database. Propensity score-matched (PSM) method was performed to balance baseline covariates. Multivariate Cox regression analysis and Kaplan-Meier curve were used to assess potential survival difference between patients undergoing surgery plus perioperative chemotherapy (SA + CT) and those undergoing surgery alone (SA).

Results

In a total of 2,711 EC patients (T1-3N0M0), 166 patients underwent SA + CT and 2,54

SUBMITTER: Shao Y 

PROVIDER: S-EPMC7947537 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature