Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65-iASPP Protein Complex.

ABSTRACT: Viruses manipulate the central machineries of host cells to their advantage. They prevent host cell antiviral responses to create a favorable environment for their survival and propagation. Measles virus (MV) encodes two nonstructural proteins MV-V and MV-C known to counteract the host interferon response and to regulate cell death pathways. Several molecular mechanisms underlining MV-V regulation of innate immunity and cell death pathways have been proposed, whereas MV-C host-interacting proteins are less studied. We suggest that some cellular factors that are controlled by MV-C protein during viral replication could be components of innate immunity and the cell death pathways. To determine which host factors are targeted by MV-C, we captured both direct and indirect host-interacting prot

SUBMITTER: Meignie A 

PROVIDER: S-EPMC7950213 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature