TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.

ABSTRACT:

Background

This study investigated the clinical implication of TNK2 expression in esophageal cancer patients' cancer tissue samples.

Methods

The expression of TNK2 in esophageal cancer tissues and para-carcinoma tissue was assessed with immunohistochemistry and Western blot analysis; besides, the proteins of CDC42, EGFR, and Akt were also analyzed. Then, Kaplan-Meier survival curves of TNK2 protein expression level were assayed with 184 esophageal cancer patients from TCGA database. Moreover, with multiple linear regression analysis, we detected the correlations of TNK2 expression associated with tumor differentiation degree and metastasis status.

Results

It revealed that TNK2 was highly expressed in the cytoplasm of esophageal cancer tissues compared with para-carcin

SUBMITTER: Zhang A 

PROVIDER: S-EPMC7958005 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature