Diastolic blood pressure predicts coronary plaque volume in patients with coronary artery disease.

ABSTRACT:

Background and aims

Hypertension is associated with increased clinical and subclinical coronary artery disease (CAD); however, the relationship between blood pressure and coronary plaque volume is unclear. We examined the effect of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on coronary artery plaque volume.

Methods

285 subjects with stable CAD on statin therapy underwent coronary computed tomographic angiography to measure volume of fatty, fibrous, noncalcified, calcified and total coronary plaque.

Results

Mean (SD) age was 63.1 (7.7); mean (SD) LDL-C, 78.7 mg/dL (28.5). Compared to the highest DBP tertile (>76 mmHg), those in the lowest DBP tertile (≤68 mmHg) had lower volumes of fatty: 10.0 vs. 7.7 mm³/mm, (p trend = 0.042), fibrous: 19.6 vs. 13.8 mm³/mm (p trend = 0.011), non-calcified: 29.7 vs. 22.5 mm³/mm (p trend = 0.017) and total plaque: 37.8 vs. 25.1 mm³/mm (p trend = 0.010) whereas there was no relationship with SBP tertiles. Similarly, when examined as a continuous variable, higher DBP was a significant independent predictor of higher plaque volume after multivariate adjustment: for every 1 mmHg increase in DBP, fibrous plaque increased 0.128 mm³/mm (p = 0.022), noncalcified plaque increased 0.176 mm³/mm (p = 0.045), calcified plaque increased 0.096 mm³/mm (p = 0.001) and total plaque increased 0.249 mm³/mm (p = 0.019) whereas SBP ranging from 95 to 154 mmHg did not predict plaque volume.

Conclusions

Level of DBP predicts coronary plaque with a DBP tertile ≤68 mmHg associated with the least amount of coronary plaque in subjects with LDL-C < 80 mg/dL.

SUBMITTER: Saleh M 

PROVIDER: S-EPMC7963403 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature